The first AIDS and saliva in our country measure reagent and is listed Can measure in half an hour

The first AIDS and saliva in our country measure reagent and is listed Can measure in half an hour
After dipping in and fetching the saliva in the oral cavity with the swab, add several kinds of different detection reagent into reagent box, whether it is infected with AIDS that very fast test happen in 30 minutes. Yesterday, the reporter promoted the centre to learn from Beijing biotechnology and new medical industry, the first AIDS and saliva in our country have measured reagent and has already been criticized and has gone on the market.
As far back as 2009, " great infectious diseases such as AIDS and virus hepatitis,etc. will be prevented and cured " in the country Under the the intersection of science and technology and great support of project, Beijing Thai biological the intersection of medicine company and Co., Ltd. and Xiamen University Wan succeed in, develop " HIV (1+2 type) The mucous membrane of oral cavity oozes out liquid antibody test reagent box " . This AIDS and saliva measure reagent and adopt the advanced immunity to percolate the law, easy and simple to handle, painless while sampling, will not cause acupuncture to damage to experimenter's skin, have reduced the risk that person measured and medical personnel are infected greatly.
This kind of saliva measures reagent, it is unsuitable to use the intravenous crowd who collected blood to suitable for some, for example children, overweight person, the intersection of vein and person who wither,etc., convenient medical terms than poor collecting blood difficult outlying district and large-scale crowd sift, use for the first time.
The HIV-positive, besides blood, their urine, oral cavity mucous membrane ooze out and contain HIV antibody in the liquid, seminal fluid and tear. At present, the saliva, urine sample of the human body of use pay AIDS and measure and arrange checking, and then combine the regular blood sample to measure, has already become the development trend that global HIV has monitored.
Before this, this reagent has already prevented the control centre at venereal disease and AIDS of Center for Disease Prevention and Control of China separately, military microbial epidemic disease research institute and Center for Disease Prevention and Control of Xinjiang Uygur Autonomous Regions of academy of medical sciences of the Chinese People's Liberation Army, have carried on the authoritative clinical research of the system, and gathered 1271 saliva samples in the nationwide high-risk group. Examine revealing, this reagent and HIV abzyme imported unite the positive coincidence rate of immune reagent and reach 99.09% in final clinic, negative coincidence rate is 99.79%, total coincidence rate is 99.61%.
"At present, a price for each person of this reagent is about one hundred yuan, not a nonprescription drug category, the pharmacy can not be bought, only suitable for epidemiology that disease accuses of the centre to investigate. " Thai medicine company general manager Qiu ZiXin Wan in Beijing says, because the collection of the saliva is simple and easy to do, this reagent can also be used in the auxiliary diagnosis that the hospital infect to HIV at the same time. "In the future, it is expected to enter the family too, become people's a way to measure AIDS oneself. "
At present, our country various existing HIV diagnoses reagent is directed against the blood sample, needs to sample the attacking, it is difficult to meet the demand that the crowd monitors, also increased the cross infection risk that may appear in the course of blood collecting at the same time. In addition our country first two AIDS measure reagent, belong to in batches finding reagent, its characterized 96 - hole board is not suitable for individual's examining, and could be operated under the aid of the professional detecting instrument.
Investigate in the backstage
Reagent inspiration comes from " First flows "
Can check the inspiration of AIDS, in fact come from " first flows " through the saliva .
In spring of 2009, " the nail will flow " in the whole world Break out, the scientific research personnel of our country research and develop " first flow " immediately Detection reagents fast,swallow by swab adopt because first, the reagents golds is getting very better in result for the colloids, scientific research personnel, through uniting the immunoreactive principle on the basis of enzyme, research and develop fast detection reagent of higher sensitivity finally, it was mainly the nasal cavity secretion and swallowing the swab to measure fast to the patient at that time.
Use the same principle, whether can apply this technology to the fast test of AIDS? It is exactly this inspiration, AIDS and saliva that just have today measure reagent.
The sensitivity is higher than foreign countries products
Compared with the situation that the existing AIDS and saliva in U.S.A. measure reagent, the intersection of reagent and enlarged result in antibody that fund research and develop newly this better, its sensitivity is 10 to 100 times higher than foreign countries products. In other words, it will be that AIDS will be measured for window period from original 4 weeks to 2 months that this will make, shorten to 3 weeks.
Human body infect behind the HIV, take, can produce antibody some time generally, can measure, arrive in the left and right blood 1 to 2 month, call the window one in this period of time, but window one is infective. Window of AIDS leak, it examines to be one global difficult problem period, new saliva measure reagent shorten window effectively one leak and examining time.
The saliva is not infected but can be examined
Since AIDS will not infect through saliva, why can examine through the saliva if then? As to this, the expert explains, the spread of HIV is mainly through the antigen, but it passes antibodies to measure.
Can measure HIV antibody in the HIV-positive's urine, saliva, tear, seminal fluid, vaginal secretion. Measure more compared with the urine, the saliva is easy to sample staff members to supervise and sample live, have avoided the influence on measuring the result of the human factor effectively.
End and sift and check the landscaped roadway as the dyke
HIV of our country reports the number of the infected is well below the actual number of the infected. 2009, Ministry of Public Health and the intersection of the United Nations and AIDS plan, assess the result, indicate jointly by administration, World Health Organization: China survive HIV-positive and the intersection of patient and about 740,000 people now. However, by the end of October of 2010, it is only 370393 that our country will report to HIV-positive and patient totally, 132440 patients among them; 68315 cases of death.
Because the society discriminates against, some people are after suspecting AIDS that oneself is infected with, often so uneasy that the hospital get, what is more to attempt to confirm by donating blood.
In fact, if AIDS can be found and treated in time, can got and controlled effectively for a long time. The saliva measures reagent, only need the person examined to include the swab for 5 minutes to take a sample in the mouth easily, can lighten psychological burden and resentment of the high-risk group.
Confirm reagent has already been researched and developed too successfully
The reporter knows, this saliva measures reagent to mainly apply to the sieve of the beginning to the person living with HIV/AIDS, and each of the infeted's definite diagnosis must be through confirming testing. And affirmation reagent of our country mainly relies on import before this, the price is probably in 400 to 500 yuan for each person share, for this reason has run off a large amount of foreign currency. Nowadays, Beijing Thai biological the intersection of medicine company and Co., Ltd. Wan succeed in, research and develop, confirm reagent by first already. It's time to confirm reagent is measured by way of collecting blood mainly, the price is far lower than the imported products. It will be expected to get the authentication codes of national Bureau of Drugs Supervision in the near future, will put into production.
The reporter experiences
It is complicated to measure the procedure to slightly show
The reporter sees at the scene, reagent boxes is made up of numerous varicoloured bottle bottle pots. It is tested that the course is quite a little complicated too. Take a sample at first, put the sponge end of collector under tongue for 5 minutes, after the sponge is softened, polish for 1 to 2 minutes back and forth on the periphery of gingivae; Push and get and measure the sponge into the device subsequently, and collect the liquid squeezed out in the sample tube Add samples to deal with liquid, enzyme and mark reagent, cleaning solution etc. in the appointed time interval separately successively hereafter, contrast the check point on reagent box and see the result afterwards, it is negative not to develop the color, it is positive to develop the color.
The expert advises experimenters to measure oneself under the guidance of professional medical worker.
The background is chained
Diagnose the development history of reagent in AIDS
In middle period of the 1990s of last century, diagnosed the reliance import of reagent in the third generation of AIDS of our country, domestic reagent still remains at the second generation of level. 1999, only piece can meet the intersection of HIV and antibody diagnose reagent box produce HIV of requirement recombinate totally in Thai company and the intersection of Xiamen University and scientific research personnel Wan develop, go abroad together Antigen, has filled in the domestic blank.
Hereafter, both sides develop our country first the third generation of the intersection of HIV and antibody diagnose the intersection of reagent and box, quality with the intersection of world and one product of miscarrying level identical, compare with domestic the second generation of product, realized the qualitative leap on sensitivity and specificity, got the national class II new medicine certificate in 2000, have finished the monopoly of the foreign corporation. At the same time, transfer the scientific findings to accounting for HIV of our country and diagnose department China above the reagent market 75% rapidly, Mei Hua, create newly, the intersection of gold and more than 10 such as being bold mainly diagnose the reagent manufacturer and face the location of sheet, make domestic HIV diagnose reagent box was realized, updated in 2001 in an all-round way, and get " The second prize of Progress in National Science and Technology " .
From 2003 to 2006, Beijing has undertaken the national development and reform committee new and high technology industrialization demonstration project " HIV recombinate antigen and antibody and diagnose reagent industrialization " Project; In 2008, the Wan 's will put out at home the fourth generation of first domestic HIV listed diagnoses reagent, further promote AIDS of our country and diagnose ability, make domestic reagent reach the international leading level.
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